What is protection group in organic chemistry?

Protecting group: A temporary group added during organic synthesis to prevent a portion of a molecule from reacting (i.e., it assists chemoselectivity). When the alcohol is protected with a tBDMS group, only the aldehyde is oxidized by Jones reagent.

What are the requirements for a protecting group?

A protecting group must fulfill a number of requirements: The protecting group reagent must react selectively (kinetic chemoselectivity) in good yield to give a protected substrate that is stable to the projected reactions. The protecting group must be selectively removed in good yield by readily available reagents.

What are amino protecting groups?

The most common α-amino-protecting groups for solid-phase peptide synthesis (SPPS) are the 9-fluorenylmethoxycarbonyl (Fmoc) and the tert-butyloxycarbonyl (Boc) groups, used in the Fmoc/tert-butyl (tBu) and Boc/benzyl (Bn) strategies respectively.

What are protecting groups give example?

A protecting group or protective group is introduced into a molecule by chemical modification of a functional group to obtain chemoselectivity in a subsequent chemical reaction. For example, the carbonyl is converted into an acetal, which does not react with hydrides.

What does a protecting group protect?

What is a protecting group? A protecting group (PG) is a molecular framework that is introduced onto a specific functional group (FG) in a poly-functional molecule to block its reactivity under reaction conditions needed to make modifications elsewhere in the molecule.

Why are protecting groups used?

Protecting groups are used in synthesis to temporarily mask the characteristic chemistry of a functional group because it interferes with another reaction. A good protecting group should be easy to put on, easy to remove and in high yielding reactions, and inert to the conditions of the reaction required.

What is the purpose of a protecting group?

What is the protecting group for alcohol?

The most common protecting groups for alcohols are the silyl ethers. Here is the idea behind it. We take a silyl chloride, do a substitution using the alcohol as a nucleophile and then the alcohol converted into a silyl ether can be used in the presence of any strong base including the Grignard reagent.

Why do we protect ketones?

The idea is that if want to make a Grignard reagent on a molecule that contains an aldehyde or ketone, we need to protect that aldehyde or ketone beforehand so that it doesn’t react with itself. Let’s walk through the example above.

What are examples of protection?

Protection is a person or thing that shields from danger, pain or discomfort, or money paid to avoid violence or prosecution. An example of protection is an umbrella to stand under during a rainstorm. An example of protection is money paid by a shopowner to the mob to avoid violence.